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Objective To investigate the clinical effect of salmeterol fluticasone propionate combined with montelukast in the treatment of moderate and severe bronchial asthma. Methods 112 patients with moderate and severe bronchial asthma in Taizhou hospital from January 2014 to December 2016 were selected and divided into the control and the study group according to the time of visiting hospital, 56 cases in each group. The control group were given salmeterol fluticasone propionate for treatment, the study group were treated with salmeterol fluticasone propionate combined with montelukast .Keep a record of the asthma control test (ACT), forced expiratory volume (FEV1) percentage expected index changes of pre-treatment and 8 weeks after treatment. Results ACT score and FEV1 percentage expected index changes of two groups there was no significant difference before the treatment. After treatment, ACT score and FEV1 percentage expected index changes of the study group was better than the control group(P<0.05). Conclusion Salmeterol fluticasone propionate combined with montelukast in the treatment can significantly improve the clinical efficacy of patients.
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Objective To investigate the effect of psychological intervention, Plavix, Aspirin Enteric-coated Tablets combined in the treatment of non ST segment elevation acute myocardial infarction. Methods 102 patients with non ST elevation acute myocardial infarction were selected in Taizhou Central Hospital from January 2015 to January 2017 and divided into study group (n=51) and control group (n=51) by single and double number (hospital admission order) method. The control group were treated with clopidogrel, Aspirin Enteric-coated Tablets, the study group on the basis of routine treatment, were given plavix, Aspirin Enteric-coated Tablets, comprehensive psychological intervention program. Results The total effective rate of the study group was 90.20%, and the total effective rate of the control group was only 70.59%, the difference was statistically significant (P<0.05). Conclusion The application of psychological intervention combined with plavix, Aspirin Enteric-coated Tablets treatment of non ST elevation acute myocardial infarction can significantly improve the clinical efficacy, to ensure the quality of life, life is of positive significance to safety.
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Objective To investigate the clinical effect of salmeterol fluticasone propionate combined with montelukast in the treatment of moderate and severe bronchial asthma. Methods 112 patients with moderate and severe bronchial asthma in Taizhou hospital from January 2014 to December 2016 were selected and divided into the control and the study group according to the time of visiting hospital, 56 cases in each group. The control group were given salmeterol fluticasone propionate for treatment, the study group were treated with salmeterol fluticasone propionate combined with montelukast .Keep a record of the asthma control test (ACT), forced expiratory volume (FEV1) percentage expected index changes of pre-treatment and 8 weeks after treatment. Results ACT score and FEV1 percentage expected index changes of two groups there was no significant difference before the treatment. After treatment, ACT score and FEV1 percentage expected index changes of the study group was better than the control group(P<0.05). Conclusion Salmeterol fluticasone propionate combined with montelukast in the treatment can significantly improve the clinical efficacy of patients.
ABSTRACT
Objective To investigate the effect of psychological intervention, Plavix, Aspirin Enteric-coated Tablets combined in the treatment of non ST segment elevation acute myocardial infarction. Methods 102 patients with non ST elevation acute myocardial infarction were selected in Taizhou Central Hospital from January 2015 to January 2017 and divided into study group (n=51) and control group (n=51) by single and double number (hospital admission order) method. The control group were treated with clopidogrel, Aspirin Enteric-coated Tablets, the study group on the basis of routine treatment, were given plavix, Aspirin Enteric-coated Tablets, comprehensive psychological intervention program. Results The total effective rate of the study group was 90.20%, and the total effective rate of the control group was only 70.59%, the difference was statistically significant (P<0.05). Conclusion The application of psychological intervention combined with plavix, Aspirin Enteric-coated Tablets treatment of non ST elevation acute myocardial infarction can significantly improve the clinical efficacy, to ensure the quality of life, life is of positive significance to safety.
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The paper investigates and analyzes the utilization of literature resources by readers in medical college libraries based on questionnaire survey to find out the problems and causes of literature resource construction work in medical college libraries,and puts forward a series of measures to improve and promote the utilization ratio of literature resources in medical college libraries and give full play to the functions of medical college libraries.
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<p><b>BACKGROUND</b>Trabecular meshwork (TM) cell volume may be an important determinant of aqueous humor outflow in the eye. This study aimed to evaluate the role of HepII domain peptides V on corneal permeability, corneal endothelial cells, intraocular pressure (IOP) and morphology of trabecular meshwork in rats.</p><p><b>METHODS</b>The IOP of rat eyes was measured before and 3, 5, 7 and 8 hours after topical delivery of HepII domain peptides V through intracameral injections. The peptide's concentration in aqueous humor was assessed by high performance liquid chromatography (HPLC). The shape and density of endothelial cells were observed by laser confocal microscopy 8 hours, 3 and 14 days after intracameral injections of HepII domain peptides V. The morphological changes in TM of rat eyes were assessed by transmission electron microscopy (TEM).</p><p><b>RESULTS</b>Intracameral injection of HepII domain peptides V significantly (P < 0.001) decreased IOP by (5.71 ± 2.10) mmHg in rats at 5 hours after injection. There were no obvious changes of the shape and the density of corneal endothelial cells. In addition, morphological changes in the TM of rats were observed including the expansion of intercellular spaces in the juxtacanalicular meshwork, removal of extracellular material, cellular relaxation, and cytoskeleton reorganization.</p><p><b>CONCLUSIONS</b>HepII domain peptides V could not penetrate cornea and was safe to corneal endothelial cells. HepII domain peptides V could significantly decrease IOP in rat probably by disorganizing actin cytoskeleton and cell-junction in the TM.</p>
Subject(s)
Animals , Female , Male , Rats , Chromatography, High Pressure Liquid , Cornea , Cell Biology , Endothelium, Corneal , Fibronectins , Chemistry , Pharmacology , Intraocular Pressure , Microscopy, Confocal , Microscopy, Electron, Transmission , Rats, Sprague-Dawley , Trabecular MeshworkABSTRACT
<p><b>OBJECTIVE</b>To explore the model and the feasibility of newborn hearing and ocular disease simultaneous screening program and to study the birth prevalence of newborn hearing loss and newborn ocular diseases.</p><p><b>METHODS</b>The universal newborn hearing screening (UNHS) was performed using transient otoacoustic emission (TEOAE) in well baby nursery and by a two-stage TEOAE and auto auditory brainstem response (AABR) protocol in neonatal intensive care unit (NICU). The UNHS was simultaneous done with newborn ocular disease screening program. The examination technical method was following: the response to light, external inspection of the eyes and lids, pupil examination, red reflex examination, funduscope examination after pupil dilation for referral (for all newborn in NICU). The infants who were referred by two-stage hearing screening and/or had high-risk factors of hearing loss received following-up and routine audiological evaluation and personalized intervention from 6 months to 3 years of age. The cases had positive sign and (or) abnormal results of the ocular disease screening were referred for further examination by pediatric ophthalmologists.</p><p><b>RESULTS</b>A total of 16 800 children born in Jinan Maternal and Child Hospital from October 1, 2002 to April 30, 2005. Of these infants, 15 398 cases (91.7%) had access to the simultaneous screening program for hearing and ocular diseases. The incidence of congenital sensorineural hearing loss (SNHL) among infants who did UNHS was 0.312% (48/15 398) in bilateral and 0.227% (35/15 398) in unilateral; Of the 4 cases of congenital SNHL complicated with newborn ocular diseases: 1 profound SNHL (bilateral), auditory neuropathy with congenital cataract (bilateral), 1 mild SNHL (bilateral) with membrana papillaris perseverance (left) and 1 mild SNHL (bilateral) with retina vein dilatation (bilateral), 1 mild SNHL (right) with persistent hyaloid artery (bilateral). In all 15 398 newborns, 15 neonates with congenital cataract were detected (22 eyes, 0.10%). Twenty seven neonates with less than 1500 g birth weight admitted to NICU, retinopathy of prematurity was detected in 3 neonates (6 eyes).</p><p><b>CONCLUSION</b>Hearing loss and ocular diseases was not rare in neonatal and infancy. Newborn hearing and ocular disease simultaneous screening program was not only feasible but also effective in detecting hearing loss and (or) ocular disorders. Early intervention was important for the prevention or treatment of neonatal hearing loss and (or) ocular diseases, such as newborn hearing loss with congenital cataract, retinopathy of prematurity and so on.</p>